This is a question that has come up multiple times with customers of mine just in the past week or so. The question? If I'm running OMEGAMON XE for DB2 PM/PE V4.20 will it support DB2 10? The answer is no. To support DB2 10 you need to install OMEGAMON DB2 V5.1 or the newly released V5.1.1. V4.20, while still a supported release, will not be retro-fitted to support DB2 10.
Until recently this has not been much of an issue, but now customers are starting to make the move to DB2 10. So it's important to realize that if DB2 10 is in your plans, now is the time to start planning to upgrade your OMEGAMON DB2 to either the V5.1 or V5.1.1 level (either one will do).